Preclinical study suggests new approach to reduce COVID-19 death among the elderly


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New research from the University of Minnesota Medical School and colleagues at the Mayo Clinic reveals a possible new approach to preventing death and severe disease in elderly people infected with SARS-CoV-2.

The researchers demonstrated in a preclinical study that senolytic drugs significantly reduced mortality upon infection from a beta-coronavirus closely related to SARS-CoV-2 in older mice. The study published in Science was co-led by Laura Niedernhofer, MD, PhD and Paul Robbins, PhD, both professors in the Department of Biochemistry, Molecular Biology and Biophysics and co-directors of the Institute on the Biology of Aging and Metabolism at the U of M Medical School, and Sara Hamilton, PhD, assistant professor in the Department of Laboratory Medicine and Pathology.



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